germe.blogg.se - Tylenol od antidote

With toxic ingestion, this system gets over-run.

NAPQI usually combines with glutathione and gets excreted (renal).

N-acetyl-P-Aminophenol (aka Tylenol) gets oxidised via CYP2E1 to N-acetyl- p-benzoquinone imine NAPQI.

Describe the metabolism of acetaminophen

other hepatic toxicities (eg, valproic acid, isoniazid, statins, herbal medications, vinyl chloride, and polychlorinated biphenyls).

cyclopeptide-containing mushroom toxicity (eg Amanita Phalloides).

In patients with elevated Liver enzymes / abnormal liver function and with or without Renal failure, think:.

Don’t forget about the differential diagnosis!.

Give the antidote = NAC when appropriate.

But with APAP overdoses there are 3 goals:.

As with all tox, don’t forget the basics (see episode 147).

18% of all unexplained liver failure ends up being attributed to APAP overdose.

The issue is its relatively a silent clinical syndrome until overt hepatocellular toxicity has ensued!.

It’s hard to find a house these days that doesn’t have a bottle or two around.

Acetaminophen (aka paracetamol aka APAP) is ubiquitous.